Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits
This study provides a comprehensive fingerprint of NOP receptor pharmacology at the single-transducer level. The lack of marked G protein bias at the NOP receptor, more pronounced than for the classical opioid receptors, may reflect a combination of intrinsic receptor properties and assay limitations. These findings underscore the need for innovative chemotypes and complementary experimental strategies to fully resolve potential transducer bias at the NOP receptor.
Authors
- Salvatore Pacifico (ORCID: https://orcid.org/0000-0002-3377-5107)
- Erika Morrone
- Nurulain T. Zaveri (ORCID: https://orcid.org/0000-0002-6850-6732)
- Remo Guerrini (ORCID: https://orcid.org/0000-0002-7619-0918)
- Davide Malfacini (ORCID: https://orcid.org/0000-0003-4562-9550)
- M. Maritan (ORCID: https://orcid.org/0000-0002-3859-230X)
- Riccardo Camilotto
- Stephen Afriyie Boateng
- Anna Vacilotto
- Girolamo Calo'
Institutions
- University of Padua (IT)
- University of Ferrara (IT)
- Astraea Therapeutics (United States) (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1111/bph.70367
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00