Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome

These findings indicated that quercetin exerted a protective effect against ARHL by suppressing NLRP3 inflammasome activation and modulating mitophagy, providing a theoretical basis for applying quercetin to treat ARHL.

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Publication Details

Journal
PLoS ONE
Published
2026-03-09
DOI
https://doi.org/10.1371/journal.pone.0342423
Primary Topic
Hearing, Cochlea, Tinnitus, Genetics
Type
article
Field-Weighted Citation Impact
0.00
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article

Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome

ZhiJi Chen, Menglong Feng, Guijun Yang, Ting Yang et al.
PLoS ONE
Hearing, Cochlea, Tinnitus, Genetics
article

Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome

ZhiJi Chen, Menglong Feng, Guijun Yang, Ting Yang, Xiaoqing Zhou, Wei Yuan, Xu Jiang
article en

Abstract

These findings indicated that quercetin exerted a protective effect against ARHL by suppressing NLRP3 inflammasome activation and modulating mitophagy, providing a theoretical basis for applying quercetin to treat ARHL.

PLoS ONEVol. 21(3)
Chongqing University (CN), Chongqing Science and Technology Commission (CN), First People's Hospital of Chongqing (CN)
Good health and well-being
Openalex Percentile: Top 25%
Hearing, Cochlea, Tinnitus, Genetics
DOIOpen Access PDFOpenAlex
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