The neuro-immuno-metabolic axis of exercise: a unified mechanistic framework for exercise-induced cognitive enhancement and psychological resilience
The NIM axis provides a novel, integrative framework that explains how metabolic stress is transduced into psychological resilience. These insights establish a theoretical foundation for precision exercise medicine and advocate for future multi-omics research to develop individualized interventions.
Authors
- Xi Cheng (ORCID: https://orcid.org/0000-0002-6706-213X)
- C Y Wang
- Jianwen Liu (ORCID: https://orcid.org/0000-0003-4149-4257)
- Haoqi Wang (ORCID: https://orcid.org/0000-0001-9002-0774)
- Zhujun Mao
- Yinghao Shen
- Yupeng Yang
- Heming Chen
- Wenyue Zhu
Institutions
- Harbin University (CN)
- China Three Gorges University (CN)
- Center for Health, Exercise and Sport Sciences (RS)
Publication Details
- Journal
- Frontiers in Psychology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fpsyg.2026.1773561
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00