A single-center retrospective study suggests a potential benefit of BTK inhibitor-based therapy in patients with histologic transformation of Waldenström macroglobulinemia
Although rare, histologic transformation from WM to DLBCL exhibits aggressive clinical behavior, frequent extranodal involvement, and poor prognosis. BTKi-based regimens may provide significant survival benefits in this patient population.
Authors
- H L Liu
- Sanmei Wang
- Xiaoyan A. Qu (ORCID: https://orcid.org/0000-0001-7581-8358)
- Yuxiao Zhao (ORCID: https://orcid.org/0009-0009-1461-1631)
- Min Xu (ORCID: https://orcid.org/0000-0001-9526-8496)
- haorui shen
- Yi Miao
- Tian Tian
- Jianyong Li
- Yi Xia
- Lei Fan
Institutions
- Soochow University (CN)
- Center for Personalized Cancer Treatment (NL)
- National Clinical Research (US)
- First Affiliated Hospital of Soochow University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1080/07853890.2026.2624909
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province