Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies
Our findings demonstrate that exercise-induced adaptations in metabolism distinctly shape the human serum metabolome and influence the metabolic response to exercise. These insights are relevant for diseases driven by dysfunctional metabolism, such as impaired fat oxidation and dysregulated glycolysis (e.g., diabetes, dementia) and muscle wasting (e.g., sarcopenia), where our specialized populations may serve as useful models.
Authors
- Daniela Schranner (ORCID: https://orcid.org/0000-0003-2316-318X)
- Annett Riermeier
- Michael A. Witting (ORCID: https://orcid.org/0000-0002-1462-4426)
- Otto Zelger
- Johannes Scherr (ORCID: https://orcid.org/0000-0001-9948-1024)
- Fabian Stöcker (ORCID: https://orcid.org/0000-0002-9422-8625)
- Henning Wackerhage (ORCID: https://orcid.org/0000-0001-5920-5842)
- A Artati
- Patrick Weinisch (ORCID: https://orcid.org/0000-0001-8430-2150)
- M. Halle
- J. Schlegel
- Stephanie Bremer
- Gabi Kastenmüller
- Jan Krumsiek
- Martin Schönfelder
- Werner Römisch-Margl
Institutions
- Cornell University (US)
- TUM Klinikum (DE)
- Helmholtz Zentrum München (DE)
- Universitätsklinik Balgrist (CH)
- German Centre for Cardiovascular Research (DE)
- Weill Cornell Medicine (US)
- Technical University of Munich (DE)
Publication Details
- Journal
- Sports Medicine - Open
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1186/s40798-026-00989-z
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00