3D-QSAR study for the development of chalcone-based inhibitors targeting ovarian cancer cells with experimental validation
CoMFA and CoMSIA models accurately predicted the activity of synthetic chalcones, and the biological findings identify these derivatives as promising candidates for the treatment of ovarian cancer, including chemoresistant forms.
Authors
- Marco Mellado (ORCID: https://orcid.org/0000-0001-9577-5180)
- Javier Echeverría (ORCID: https://orcid.org/0000-0002-1688-968X)
- Marcos Lorca
- Jaime Mella
- Mariaignacia Rubilar
- Manuel Valenzuela-Valderrama
- Christian Espinosa-Bustos
- Aranxa Varas
Institutions
- Universidad de Santiago de Chile (CL)
- Pontificia Universidad Católica de Chile (CL)
- Viña del Mar University (CL)
- Universidad Bernardo O'Higgins (CL)
- Centro de Investigación y Desarrollo (ES)
- Universidad Central de Chile (CL)
- University of Valparaíso (CL)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fphar.2026.1746658
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Nacional de Investigación y Desarrollo