Investigation of the impact of resveratrol on sublethal-dose ALA-PDT in glioblastoma cells

This study demonstrates that the combination of Res and ALA-PDT enhances the inhibition of glioblastoma cell growth compared to the single treatments. The combined therapy can induce apoptosis and autophagy in GBM cells by suppressing the ERK1/2 and mTOR signaling pathways, providing a potential new treatment for GBM. However, in vivo validation and clinical trials are essential for fully evaluating the potential of this mechanism regarding translation into clinical application.