Total alkaloids of Leonurus alleviate allergic asthma and inflammation responses by inhibiting hypoxia-induced factor-1⍺-mediated mast cell activation
TAL alleviates allergic asthma by suppressing HIF-1α-mediated mast cell activation and associated inflammation responses, supporting its potential application in inflammatory airway diseases.
Authors
- Zhichao Xi
- Trinh T. Nguyen (ORCID: https://orcid.org/0000-0002-4019-3375)
- Hongmei Zhang (ORCID: https://orcid.org/0000-0003-3557-0364)
- Song‐Lin Li (ORCID: https://orcid.org/0000-0003-1354-7729)
- M. Yuan (ORCID: https://orcid.org/0000-0002-0991-5026)
- Yannan Zheng
- Min Zheng (ORCID: https://orcid.org/0000-0002-3319-5647)
- Hongxi Xu
- Mingyue Lv
- Shijie Wan
- Hua Li
- Mengfan Liu
- Jijia Sun
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Jiangsu Provincial Academy of Traditional Chinese Medicine (CN)
- China Academy of Chinese Medical Sciences (CN)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fphar.2026.1783196
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China