PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification

PD03 inhibits thrombin-induced activation of the IL-1β-mediated feedback loop between the MEK-Erk1/2 and NF-κB pathways, thereby restoring bone formation and offering a promising therapeutic approach for mitigating bone loss in patients with elevated thrombin levels.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-03-09
DOI
https://doi.org/10.3389/fimmu.2026.1730337
Primary Topic
Bone Metabolism and Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification

Min-Jun Zhao, Xuezong Wang, Y Wang, Junwei Shen et al.
Frontiers in Immunology
Bone Metabolism and Diseases
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PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification

Min-Jun Zhao, Xuezong Wang, Y Wang, Junwei Shen, Ting-Ting Meng, Yang-Shuo null Ge, Dao-Fang null Ding, Liao-Lin null Chen, Jia-Hui null Luo, Yu-Qing null Zhai, Xin-Hui null Huang, Ping-Ping Sun, Chun-Meng Huang, Jian-Li Yin, Jia-Wei Du
article en

Abstract

PD03 inhibits thrombin-induced activation of the IL-1β-mediated feedback loop between the MEK-Erk1/2 and NF-κB pathways, thereby restoring bone formation and offering a promising therapeutic approach for mitigating bone loss in patients with elevated thrombin levels.

Frontiers in ImmunologyVol. 17
Shanghai University of Traditional Chinese Medicine (CN), Shanghai Second People's Hospital (CN), Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine (CN), Shuguang Hospital (CN)
Openalex Percentile: Top 28%
Bone Metabolism and Diseases
DOIOpen Access PDFOpenAlex
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