Metabolomic Profiling of Fecal Samples Reveals Distinct Signatures Associated with Disease Phenotypes and Locations in Crohn’s Disease
This study reveals metabolomic differences across CD phenotypes and disease activity, providing potential noninvasive biomarkers to help risk-stratify patients for complications and guide tailored management. Further validation in larger cohorts is warranted.
Authors
- Parakkal Deepak (ORCID: https://orcid.org/0000-0002-3436-9784)
- Themistocles Dassopoulos (ORCID: https://orcid.org/0000-0003-2968-0321)
- Richard H. Duerr (ORCID: https://orcid.org/0000-0001-6586-3905)
- Tingyi Tan
- Umang Jain (ORCID: https://orcid.org/0000-0002-0220-8230)
- Sheldon Lidofsky
- Rebecca Matro (ORCID: https://orcid.org/0000-0002-4134-0963)
- Scott B. Snapper (ORCID: https://orcid.org/0000-0003-0267-4247)
- Sushila Dalal (ORCID: https://orcid.org/0000-0003-1207-0500)
- Manreet Kaur (ORCID: https://orcid.org/0000-0001-8716-8882)
- Meenakshi Bewtra (ORCID: https://orcid.org/0000-0002-6489-7043)
- Kirk Russ (ORCID: https://orcid.org/0000-0002-3088-7277)
- Shrinivas Bishu
- Gauree G. Konijeti (ORCID: https://orcid.org/0000-0003-4221-4579)
- Lauren George (ORCID: https://orcid.org/0000-0002-2943-9266)
- Ray Cross
- Mazer Ally
- Poonam Beniwal-Patel
- James A. Lewis
- Sumona Saha
- Satya Kudara
- SPARC I. B. D. Investigators
- Elizabeth Scoville
- Richa Shukla
- Joel Pekow
- Freddy Caldera
- Laura Raffals
- David Hudesman
- Kara De Felice
- Matthew Vincent
- Josh Korzenik
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1007/s10620-026-09779-9
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- University of Pennsylvania
- NYU Langone Medical Center
- University of Pittsburgh
- University of Cincinnati
- Scheme for Promotion of Academic and Research Collaboration