Antipsychotic-induced weight gain in psychosis: causal mediation analysis and feasibility study of causal actionable prediction model development using counterfactuals to target obesity
Our results show that it may be early rather than later weight change that causally mediates antipsychotic-induced weight gain at 1 year. They also demonstrate the potential for causal actionable prediction of counterfactuals for true precision medicine, although this is tempered by the feasibility scope of this study and small sample size. Our results are hypothesis-generating and not yet clinically deployable.
Authors
- SM Lawrie
- Damian Machlanski (ORCID: https://orcid.org/0000-0003-4819-8565)
- Rajeev Krishnadas (ORCID: https://orcid.org/0000-0001-6845-5894)
- Sotirios Tsaftaris
- Samuel Leighton (ORCID: https://orcid.org/0000-0002-3999-4204)
- Fani Deligianni (ORCID: https://orcid.org/0000-0003-1306-5017)
- I Lam Leong
- Benjamin I. Perry
Institutions
- University of Cambridge (GB)
- University of Glasgow (GB)
- University of Birmingham (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- The British Journal of Psychiatry
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1192/bjp.2026.10561
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- National Institute for Health and Care Research
- Department of Health and Social Care
- Engineering and Physical Sciences Research Council
- NIHR Cambridge Biomedical Research Centre
- Scottish Mental Health Research Network