SARS−CoV−2 spike S1-mediated HIF−2α activation in retinal endothelial cells suggests a mechanism contributing to post−COVID endothelial dysfunction
These findings identify a spike-responsive, HIF-2α-associated ED pathway in retinal endothelial cells. Modulation of this pathway altered endothelial barrier responses to both recombinant S1 and plasma from patients with PCS, highlighting a candidate mechanism that may contribute to PCS-associated vascular dysfunction.
Authors
- Christoph Schmaderer (ORCID: https://orcid.org/0000-0002-5803-2190)
- Johanna Negele
- Maciej Lech (ORCID: https://orcid.org/0000-0002-4293-2733)
- Kristina Adorjan (ORCID: https://orcid.org/0000-0001-7501-9556)
- Anna Wöhnl
- Veronika Kesseler
- M. Seifert
- Timon Wallraven (ORCID: https://orcid.org/0009-0006-4499-1223)
- Hans Christian Stubbe
- Andrea Ribeiro
Institutions
- University of Bern (CH)
- TUM Klinikum (DE)
- LMU Klinikum (DE)
- Humboldt-Universität zu Berlin (DE)
- German Center for Infection Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fimmu.2026.1770758
- Primary Topic
- Retinal and Optic Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00