Model-Informed Precision Dosing of Protein Kinase Inhibitors: Evaluation of Model-Averaging and Flattened Priors Methods
The benefit of the model-averaging method for the model-informed precision dosing of sunitinib and pazopanib is likely applicable to other protein kinase inhibitors. Thanks to 'mapbayr', this framework was implemented as a standalone shiny application to be used in clinical settings.
Authors
- Étienne Chatelut (ORCID: https://orcid.org/0000-0002-7740-9096)
- Florent Puisset (ORCID: https://orcid.org/0000-0002-3083-5784)
- Laura Morvan
- Félicien Le Louedec (ORCID: https://orcid.org/0000-0003-3699-2729)
- Christelle Vachoux
- Helen Boyle (ORCID: https://orcid.org/0000-0002-8201-948X)
- Malika Yakoubi
- Frédéric Thuillier
- Guilhem Roubaud
- L. Mourey
- F. Thomas
- Mélanie White-Koning
- Maud Maillard
- Gwenaelle Gravis
- Diego Tosi
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre de Recherches en Cancérologie de Toulouse (FR)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Centre Léon Bérard (FR)
- Centre Hospitalier Universitaire de Limoges (FR)
- Institut Claudius Regaud (FR)
- Institut Bergonié (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Centre de Recherche en Cancérologie de Marseille (FR)
- Institut Paoli-Calmettes (FR)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1007/s40262-026-01628-2
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université de Toulouse