A population-scale Red Blood Cell proteome atlas of 13,000 donors uncovers genetically encoded aging clocks predicting hemolysis, transfusion efficacy, and donor activity a decade later
RBC proteome atlas of 13,091 donors reveals demographic and genetic programsGenetically encoded RBC aging clocks identify regulators of molecular ΔageMolecular aging features predict hemolysis and transfusion response across cohortsRBC molecular age forecasts long-term donor activity over a 12-year follow-up.
Authors
- Julie A. Reisz (ORCID: https://orcid.org/0000-0002-7296-4963)
- Shaun Bevers (ORCID: https://orcid.org/0000-0002-2000-6106)
- Gregory R. Keele (ORCID: https://orcid.org/0000-0002-1843-7900)
- Xunde Wang
- Travis G. Nemkov (ORCID: https://orcid.org/0000-0001-8566-7119)
- Zachary B. Haiman (ORCID: https://orcid.org/0000-0001-6175-5050)
- Anthony J. Saviola (ORCID: https://orcid.org/0000-0001-6890-512X)
- Aaron Issaian (ORCID: https://orcid.org/0000-0001-9762-5098)
- Eldad A. Hod (ORCID: https://orcid.org/0000-0002-2367-9509)
- Steve Kleinman
- Monika Ewa Dzieciatkowska
- Mars Stone
- Swee-Lay Thein
- Grier P. Page
- Fang Fang
- Xutao Deng
- Daniel Stephenson
Institutions
- Kaiser Permanente (US)
- University of British Columbia (CA)
- RTI International (US)
- University of California, San Francisco (US)
- Pacific Research Institute (US)
- National Heart, Lung, and Blood Institute (US)
- Touch of Life Technologies (United States) (US)
- Vitalant (US)
- University of Colorado Anschutz Medical Campus (US)
- Columbia University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-08
- DOI
- https://doi.org/10.64898/2026.03.07.710284
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00