The m5C demethylase TET1 is identified as a key regulator of scleral remodeling in myopia

Our study reveals substantial alterations in TET1 expression and m<sup>5</sup>C modification in myopic sclera, providing new insights that may inform the development of novel diagnostic and therapeutic approaches for myopia management.

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Publication Details

Journal
Clinical Epigenetics
Published
2026-03-09
DOI
https://doi.org/10.1186/s13148-026-02099-9
Primary Topic
Ophthalmology and Visual Impairment Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

The m5C demethylase TET1 is identified as a key regulator of scleral remodeling in myopia

Shichong Jia, P. Wei, Ludi Yang, Yan Wang et al.
Clinical Epigenetics
Ophthalmology and Visual Impairment Studies
article

The m5C demethylase TET1 is identified as a key regulator of scleral remodeling in myopia

Shichong Jia, P. Wei, Ludi Yang, Yan Wang, Jie Yu, Guoge Han
article en

Abstract

Our study reveals substantial alterations in TET1 expression and m<sup>5</sup>C modification in myopic sclera, providing new insights that may inform the development of novel diagnostic and therapeutic approaches for myopia management.

Clinical Epigenetics
Shanghai Jiao Tong University (CN), Nankai University (CN), Shanghai Ninth People's Hospital (CN), Tianjin Medical University Eye Hospital (CN), Tianjin Medical University (CN)
Sustainable cities and communities
Openalex Percentile: Top 30%
Ophthalmology and Visual Impairment Studies
DOIOpen Access PDFOpenAlex
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The m5C demethylase TET1 is identified as a key regulator of scleral remodeling in myopia — Shichong Jia, P. Wei, et al. · Clinical Epigenetics (2026) | TGRS Research Map | TGRS