Medication effects on cue‐induced craving in the human laboratory are associated with return to heavy drinking in randomized clinical trials for alcohol use disorder: A follow‐up meta‐analysis
Medications that produce greater reductions in cue-induced alcohol craving appear to be associated with lower rates of return to heavy drinking, but not consistently with other drinking outcomes. This pattern indicates that the cue-reactivity paradigm has limited and outcome-specific translational validity rather than functioning as a universal indicator of clinical efficacy.
Authors
- Lindsay R. Meredith (ORCID: https://orcid.org/0000-0001-7584-9488)
- Steven J. Nieto (ORCID: https://orcid.org/0000-0003-1158-5211)
- Kaitlin R. McManus
- Molly Magill (ORCID: https://orcid.org/0000-0001-5041-4664)
- Suzanna Donato (ORCID: https://orcid.org/0000-0002-5865-3384)
- Han Du (ORCID: https://orcid.org/0000-0001-5516-3032)
- Lara A. Ray
- Wave‐Ananda Baskerville
Institutions
- University of California, Los Angeles (US)
- Wayne State University (US)
- Brown University (US)
- Neurobehavioral Systems (US)
Publication Details
- Journal
- Addiction
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1111/add.70373
- Primary Topic
- Substance Abuse Treatment and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00