Effectiveness of Stimulant Treatment in Preventing Fractures and Head Injuries in Patients With Narcolepsy: A Self‐Controlled Case Series Study

Our results indicate that overall stimulant use did not decrease the risk of fracture or head injury in patients with narcolepsy. However, methylphenidate may help prevent fractures. Clinicians should balance the safety and effectiveness of each stimulant with additional preventive strategies for injury.

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Publication Details

Journal
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
Published
2026-03-09
DOI
https://doi.org/10.1002/phar.70132
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Effectiveness of Stimulant Treatment in Preventing Fractures and Head Injuries in Patients With Narcolepsy: A Self‐Controlled Case Series Study

Soichiro Masuda, Koji Kawakami, Takayuki Anno, Masato Takeuchi et al.
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
Sleep and Wakefulness Research
article

Effectiveness of Stimulant Treatment in Preventing Fractures and Head Injuries in Patients With Narcolepsy: A Self‐Controlled Case Series Study

Soichiro Masuda, Koji Kawakami, Takayuki Anno, Masato Takeuchi, Yunlong Zheng, Toshiki Fukasawa
article en

Abstract

Our results indicate that overall stimulant use did not decrease the risk of fracture or head injury in patients with narcolepsy. However, methylphenidate may help prevent fractures. Clinicians should balance the safety and effectiveness of each stimulant with additional preventive strategies for injury.

Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyVol. 46(4)
Kyoto University (JP)
Good health and well-being
Openalex Percentile: Top 33%
Sleep and Wakefulness Research
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