Naoxintong capsule decreases circulating exosomes of miR-382-5p to protect LPS-induced vascular endothelial cell injury by targeting STC1 in vitro
Our findings elucidated that NXT protected HMEC-1 from injury and dysfunction by downregulating miR-382-5p in circulating exosomes, potentially via targeting <i>STC1</i> and inhibiting the TLR4/TRIF/NF-κB pathway.
Authors
- Y. Q. Chen (ORCID: https://orcid.org/0000-0002-3572-1006)
- Weiwei Su
- Wei Fan (ORCID: https://orcid.org/0000-0001-5418-1714)
- Fenzhao Meng
- Ziyan Xu
- Muhan Zou
- Songnian Hu (ORCID: https://orcid.org/0000-0003-3966-3111)
- Peibo Li
- Hao Wu
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fphar.2026.1655883
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00