Assembly of a pangenome uncovers novel non-reference unique insertion sequences in cattle highlighting their genetic diversity
Our findings demonstrate the value of pangenome approaches to uncover functionally relevant SVs, particularly NRUIs, that are systematically not in the current reference genome. By linking these variants to economically important traits, our work underscores the need to incorporate breed diversity into future genomic analyses and reference-building efforts in cattle.
Authors
- Aurélien Capitan (ORCID: https://orcid.org/0000-0003-3185-0932)
- Carole Iampietro (ORCID: https://orcid.org/0000-0002-8148-4785)
- F. Besnard (ORCID: https://orcid.org/0000-0002-1187-9132)
- Clémentine Escouflaire (ORCID: https://orcid.org/0000-0003-3586-9761)
- Maulana M. Naji (ORCID: https://orcid.org/0000-0002-3264-2708)
- Laurence Drouilhet (ORCID: https://orcid.org/0000-0003-0407-9820)
- Camille Eché (ORCID: https://orcid.org/0000-0002-1460-0969)
- Joanna Lledo (ORCID: https://orcid.org/0000-0001-7239-2259)
- Cécile Grohs (ORCID: https://orcid.org/0000-0002-3563-8966)
- Sébastien Fritz (ORCID: https://orcid.org/0000-0002-3378-1048)
- Valentin Sorin
- G. Tosser-Klopp
- D. Boichard
- M. Boussaha
- Denis Milan
- Christophe Klopp
- Cécile Donnadieu
- Marie-Pierre Sanchez
Institutions
- École Nationale Vétérinaire de Toulouse (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- AgroParisTech (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Génétique Physiologie et Systèmes d'Elevage (FR)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1186/s40104-026-01373-3
- Primary Topic
- Genetic and phenotypic traits in livestock
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Région Occitanie Pyrénées-Méditerranée