Integrative analysis reveals luteolin’s molecular targets and mechanisms in pancreatic cancer treatment

This study identifies MET as a critical therapeutic target of luteolin in pancreatic cancer, providing mechanistic insights into luteolin's anti-cancer effects via the MET/PI3K/AKT signaling pathway and supporting its potential clinical application.

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Publication Details

Journal
European journal of medical research
Published
2026-03-09
DOI
https://doi.org/10.1186/s40001-026-04056-x
Primary Topic
FOXO transcription factor regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Integrative analysis reveals luteolin’s molecular targets and mechanisms in pancreatic cancer treatment

Lili Chen, Danhong Pan, Peixi Zhong, Shixia Li et al.
European journal of medical research
FOXO transcription factor regulation
article

Integrative analysis reveals luteolin’s molecular targets and mechanisms in pancreatic cancer treatment

Lili Chen, Danhong Pan, Peixi Zhong, Shixia Li, Binbo Fang, Yifu Feng
article en

Abstract

This study identifies MET as a critical therapeutic target of luteolin in pancreatic cancer, providing mechanistic insights into luteolin's anti-cancer effects via the MET/PI3K/AKT signaling pathway and supporting its potential clinical application.

European journal of medical research
Taizhou Central Hospital (CN), The First People's Hospital of Wenling (CN), Taizhou University (CN)
Good health and well-being
Openalex Percentile: Top 28%
FOXO transcription factor regulation
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