Prospective multicentre study of upper respiratory mucosal transcriptomics reveals two major endotypes of critically ill COVID-19 patients
This study highlights the heterogeneity of the immune response in critically-ill COVID-19 patients in the Omicron era, identifies two endotypes from the analysis of upper airway mucosal transcriptomics. Our findings suggest the existence of two distinct pathogenic mechanisms and the detrimental role of neutrophil and Th2 helper cell-mediated inflammation in a subset of patients with severe disease. They support the need for personalised treatment strategies targeting neutrophil-mediated lung damage and/or specific cytokine production in a subset of critically-ill COVID-19 patients.
Authors
- Laure Boizeau
- A. Pitsch
- Marilyn Ader (ORCID: https://orcid.org/0000-0003-3690-9745)
- Sébastien Jochmans (ORCID: https://orcid.org/0000-0002-7111-4107)
- Amandine Henry
- Elyanne Gault (ORCID: https://orcid.org/0000-0003-3855-9304)
- Amal Chaghouri
- Alexandre Soulier
- Stefano Caruso (ORCID: https://orcid.org/0000-0002-6319-3642)
- Laurence Morand-Joubert (ORCID: https://orcid.org/0009-0002-7269-2328)
- Aurélie Guigon
- Pierre Bay
- Matthieu Turpin (ORCID: https://orcid.org/0000-0001-6824-4464)
- Jean-Michel Pawlotsky
- Slim Fourati
- Quentin Le Hingrat
- Damien Contou
- Adrien Joseph
- Sébastien Préau
- Damien Roux
- Lynda Handala
- Christophe Rodriguez
- Tài Pham
- Nicolas de Prost
- Nicholas Heming
- Raphaël Favory
- Antoine Guillon
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Université de Tours (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université Paris Cité (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Hôpital Louis-Mourier (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Antoine (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Melun Hospital (FR)
- Thion Medical (France) (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Hôpital Ambroise-Paré (FR)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- Centre de Recherche Saint-Antoine (FR)
- Hôpital Raymond-Poincaré (FR)
- Centre Hospitalier Victor Dupouy (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Institut Mondor de Recherche Biomédicale (FR)
- Bicêtre Hospital (FR)
- Hôpital Paul-Brousse (FR)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1038/s43856-026-01474-0
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00