Identification of core genes mediating the association between obesity and hepatocellular carcinoma: A bioinformatics study based on mitochondrial metabolism and immune pathways

ACAA1 and potentially ADI1 are downregulated candidate genes linking obesity to HCC. Their suppression likely drives obesity-related HCC progression by coupling mitochondrial metabolic reprogramming with immunosuppressive tumor microenvironment remodeling, representing potential therapeutic targets.

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Publication Details

Journal
PLoS ONE
Published
2026-03-09
DOI
https://doi.org/10.1371/journal.pone.0344452
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Identification of core genes mediating the association between obesity and hepatocellular carcinoma: A bioinformatics study based on mitochondrial metabolism and immune pathways

Rui Min, Xiaocan Li
PLoS ONE
Ferroptosis and cancer prognosis
article

Identification of core genes mediating the association between obesity and hepatocellular carcinoma: A bioinformatics study based on mitochondrial metabolism and immune pathways

Rui Min, Xiaocan Li
article en

Abstract

ACAA1 and potentially ADI1 are downregulated candidate genes linking obesity to HCC. Their suppression likely drives obesity-related HCC progression by coupling mitochondrial metabolic reprogramming with immunosuppressive tumor microenvironment remodeling, representing potential therapeutic targets.

PLoS ONEVol. 21(3)
Nanchang University (CN)
Openalex Percentile: Top 28%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
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Identification of core genes mediating the association between obesity and hepatocellular carcinoma: A bioinformatics study based on mitochondrial metabolism and immune pathways — Rui Min, Xiaocan Li · PLoS ONE (2026) | TGRS Research Map | TGRS