Metabolic reprogramming induced by CRP deficiency or human CRP transgenic in influenza-infected mice

These findings demonstrate that CRP deficiency or human CRP transgenic induces distinct metabolic reprogramming post-infection. Metabolic alterations, particularly in energy redistribution, antioxidant defense, and immune-related pathways, may serve as biomarkers for disease progression in severe influenza. The results highlighted CRP's role in balancing metabolic and immune homeostasis during viral infection.