Systemic immuno-metabolic inflammatory indices (neutrophil-to-HDL cholesterol ratio and systemic inflammation response index) are strongly associated with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched study

Systemic immuno-metabolic inflammatory indices reflecting innate immune activation and lipid-related anti-inflammatory dysfunction (NHR and SIRI) are closely associated with MASLD. The combined assessment of NHR, SIRI, and ALT provides a robust, clinically accessible approach with significant incremental value for identifying immuno-metabolic risk in MASLD, highlighting the central role of systemic immune dysregulation in metabolic liver disease.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-03-09
DOI
https://doi.org/10.3389/fimmu.2026.1768302
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Systemic immuno-metabolic inflammatory indices (neutrophil-to-HDL cholesterol ratio and systemic inflammation response index) are strongly associated with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched study

Haize Ge, Boqiao Wang, Pengjiao Xi, Zhongzhong Zhang et al.
Frontiers in Immunology
Liver Disease Diagnosis and Treatment
article

Systemic immuno-metabolic inflammatory indices (neutrophil-to-HDL cholesterol ratio and systemic inflammation response index) are strongly associated with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched study

Haize Ge, Boqiao Wang, Pengjiao Xi, Zhongzhong Zhang, Jinyang Li, Chengwei Zhang, Jianwei Zhang, Xu Chen, Jie Yang, Huimin Liang, Yan Zhang, Yijia Xu, Deyuan Zhang
article en

Abstract

Systemic immuno-metabolic inflammatory indices reflecting innate immune activation and lipid-related anti-inflammatory dysfunction (NHR and SIRI) are closely associated with MASLD. The combined assessment of NHR, SIRI, and ALT provides a robust, clinically accessible approach with significant incremental value for identifying immuno-metabolic risk in MASLD, highlighting the central role of systemic immune dysregulation in metabolic liver disease.

Frontiers in ImmunologyVol. 17
Tianjin University of Science and Technology (CN), Sun Yat-sen University (CN), Tianjin Third Central Hospital (CN), Shanxi Academy of Medical Sciences (CN), Eighth Affiliated Hospital of Sun Yat-sen University, Tianjin Medical University (CN), East China Normal University (CN)
Reduced inequalities
Openalex Percentile: Top 30%
Liver Disease Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Systemic immuno-metabolic inflammatory indices (neutrophil-to-HDL cholesterol ratio and systemic inflammation response index) are strongly associated with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched study — Haize Ge, Boqiao Wang, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS