Risk factors and management strategies in acute promyelocytic leukemia: a real-world single-center retrospective study
This study found that high initial WBC count, prolonged PT, and CD2 positivity are critical independent predictors of ED in APL. The findings underscore the necessity of prompt diagnosis, risk-adapted therapy, and comprehensive multidisciplinary care, including aggressive management of coagulopathy. Enhanced CNS prophylaxis should be considered for high-risk patients to prevent relapse.
Authors
- Yewei Wang (ORCID: https://orcid.org/0000-0002-2213-5198)
- Doudou Tang
- Hai Zhong (ORCID: https://orcid.org/0000-0002-4544-9915)
- M Chen (ORCID: https://orcid.org/0009-0003-5604-5777)
- Huihui Wang (ORCID: https://orcid.org/0000-0002-4098-5313)
- Yafeng Jiang
- Guangsen Zhang
- Hongling Peng
Institutions
- Central South University (CN)
- Shanghai CASB Biotechnology (China) (CN)
- Hunan Province Chest Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fmed.2026.1752909
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- QIMR Berghofer Medical Research Institute
- Health Commission of Hunan Province