Pediatric Hepatoblastoma: From Developmental Molecular Mechanisms to Innovative Therapeutic Strategies
Future progress in pediatric hepatoblastoma will require a paradigm shift from purely clinicopathological management toward an integrated molecular and surgical framework. Incorporating biological stratification into therapeutic decision-making may enable personalized treatment, rational therapy de-escalation, and improved outcomes for high-risk disease. This review highlights the foundations and future directions for precision medicine in hepatoblastoma.
Authors
- Alina Jehac
- Valentin Bernic (ORCID: https://orcid.org/0000-0003-4644-6721)
- Alina Belu
- Ana Maria Scurtu
- Elena Cojocaru (ORCID: https://orcid.org/0000-0002-0033-4620)
- I. Mȃrţu
- Laura Mihaela Trandafir
- Viorel Țarcă
- Rodica Elena Heredea
- Elena Țarcă
- Dumitrel Băiceanu
Institutions
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Apollonia University (RO)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
Publication Details
- Journal
- Cancers
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3390/cancers18050879
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00