Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery

In this work, the usability of tamoxifen-loaded alginate/chitosan nanoparticles as a drug release system was investigated. Optimal conditions for nanoparticle preparation were determined, and the nanoparticles were characterized using Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), and scanning electron microscopy (SEM). According to AFM and SEM images, the nanoparticles ranged in size from 50 to 800 nm. The release of tamoxifen from nanoparticles in simulated stomach and small intestine media was investigated, and it was found that after 5 h, only 8% of the immobilized drug was released in the stomach medium, whereas 92% was released in the small intestine medium. The results show that tamoxifen-loaded alginate/chitosan nanoparticles have the potential to serve as a controlled drug-delivery system.