Dihydropyrimidine dehydrogenase (DPYD) genetic testing and treatment with 5-fluoropyrimidines in cancer patients: prevalence of variants with decreased activity and chemotherapy outcomes
A sizable minority of oncology patients bear variants of DPYD with reduced activity and may be at increased risk of fluoropyrimidine toxicities if treated at full doses. However, variability within the same genotype exists.
Authors
- Michela Febbraro (ORCID: https://orcid.org/0000-0002-9155-7773)
- C Rosso
- Ioannis A. Voutsadakis (ORCID: https://orcid.org/0000-0002-9301-5951)
Institutions
- University of Iowa Hospitals and Clinics (US)
- Sault Area Hospital (CA)
- NOSM University (CA)
Publication Details
- Journal
- Pharmacogenomics
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1080/14622416.2026.2641748
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00