Amphiregulin attenuates sepsis-induced myocardial dysfunction by maintaining the localization of connexin43
This study highlights the role of Cx43 phosphorylation in SIMD and demonstrates the preventive potential of AREG in SIMD, which is associated with a reduction in p38 activation and a decrease in the phosphorylation level of p<sup>S368</sup>-Cx43. These findings may provide a novel therapeutic target for SIMD.
Authors
- Shintaro Kinugawa (ORCID: https://orcid.org/0000-0003-2559-0054)
- Koichi Isayama
- Shinnosuke Takamori
- Masanori Honsho (ORCID: https://orcid.org/0000-0001-6165-4516)
- Yuqing Wang (ORCID: https://orcid.org/0009-0006-2028-8138)
- Shuntaro Matsunaga
- Masaharu Murata
- Sayoko Narahara
- Tomohiko Akahoshi
- Man Chen
- Kohtaro Abe
Institutions
- Kyushu University (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1186/s41232-026-00410-y
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00