Advancements in aptasensors development for the detection of zearalenone

Zearalenone (ZEN), an estrogenic mycotoxin produced by <i>Fusarium</i> species, is a frequent contaminant in cereals and other agricultural commodities. Its presence poses substantial economic losses, threatens food safety, and presents significant risks to human health, making it a growing concern worldwide. Consequently, the development of rapid, sensitive, and reliable methods for ZEN detection is of critical importance. In recent years, aptasensors technologies have emerged as promising tools for mycotoxin monitoring. This review comprehensively summarizes recent advances in ZEN-specific aptasensors, with a focus on detection mechanisms, analytical performance, and comparative advantages and limitations of various platforms. By providing an up-to-date overview of optical, electrochemical, and other emerging sensing strategies, this work aims to support future developments in mycotoxin prevention and detection, thereby contributing to enhanced food safety assurance.