Adjunctive semaglutide improves metabolic outcomes in patients with schizophrenia

Weekly injections of semaglutide over 26 weeks were more effective than matching placebo in improving glycemic control and weight outcomes in patients with schizophrenia who received clozapine or olanzapine, a randomized trial has found. Participants receiving semaglutide did not experience a disproportionate number of adverse events. Study results were published online Dec. 3, 2025 in JAMA Psychiatry .

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2026-02-23
DOI
https://doi.org/10.1002/pu.31414
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Adjunctive semaglutide improves metabolic outcomes in patients with schizophrenia

The Brown University Psychopharmacology Update
Diabetes Treatment and Management
article

Adjunctive semaglutide improves metabolic outcomes in patients with schizophrenia

article en

Abstract

Weekly injections of semaglutide over 26 weeks were more effective than matching placebo in improving glycemic control and weight outcomes in patients with schizophrenia who received clozapine or olanzapine, a randomized trial has found. Participants receiving semaglutide did not experience a disproportionate number of adverse events. Study results were published online Dec. 3, 2025 in JAMA Psychiatry .

The Brown University Psychopharmacology UpdateVol. 37(3)
Good health and well-being
Openalex Percentile: Top 30%
Diabetes Treatment and Management
DOISourceOpenAlex
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Adjunctive semaglutide improves metabolic outcomes in patients with schizophrenia · The Brown University Psychopharmacology Update (2026) | TGRS Research Map | TGRS