Identification of PANoptosis hub genes driving immune activation and tubulointerstitial injury in diabetic kidney disease by integrative bioinformatics and machine learning
This study delineates extensive perturbations and crosstalk among apoptosis, pyroptosis and necroptosis in DKD, positioning PANoptosis as a unifying driver of tubulointerstitial injury. The six PANoptosis hub genes and their derived PRS show strong diagnostic potential, while integrated regulatory and druggability analyses nominate <i>CASP1, FAS, PSMB9</i> and <i>PRKACB</i> as promising biomarkers and therapeutic entry points for PANoptosis-centered interventions in DKD.
Authors
- Xing Zeng (ORCID: https://orcid.org/0000-0001-8229-5903)
- Lerong Liu (ORCID: https://orcid.org/0000-0001-8379-910X)
- S. Li (ORCID: https://orcid.org/0009-0005-2381-1732)
- Yang Liu
- Tao Chen (ORCID: https://orcid.org/0000-0001-9704-9545)
- Yu Chen (ORCID: https://orcid.org/0000-0002-0171-3884)
- Feifei Yuan
- Xuankun Peng
- Tongfeng Zhao
Institutions
- University of Science and Technology of China (CN)
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fimmu.2026.1759781
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00