Development and validation of an ultra-sensitive UPLC-MS/MS method for quantification of monomethyl auristatin E in cynomolgus monkey plasma: application to pharmacokinetic study
This validated method is instrumental in exploring the in vivo pharmacokinetic profile of ADC and elucidating their exposure-response dynamics.
Authors
- Yi Tao (ORCID: https://orcid.org/0000-0001-6838-0749)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-0254-5843)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-9531-2223)
- Yanfeng Liu (ORCID: https://orcid.org/0000-0002-0562-9647)
- Weimin Hu
- Lili Xing
- Liang Shen
- Rui Diao
Institutions
- WuXi AppTec (China) (CN)
- WuXi AppTec (United States) (US)
Publication Details
- Journal
- Bioanalysis
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1080/17576180.2026.2641573
- Primary Topic
- Bioactive Compounds in Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00