L-carnitine ameliorates fibrosis and reproductive dysfunction in intrauterine adhesion via restoration of mitochondrial fatty acid oxidation
This study establishes carnitine deficiency as a key driver of IUA, demonstrating that it disrupts mitochondrial FAO, promotes oxidative stress, and culminates in fibrosis. LCA supplementation not only restores metabolic homeostasis and reduces fibrotic progression but also improves reproductive outcomes, positioning it as a mechanistically grounded therapy for IUA.
Authors
- Congquan Wu
- Qing Cai (ORCID: https://orcid.org/0000-0003-4930-2256)
- MingQing Li
- Ke Peng (ORCID: https://orcid.org/0000-0002-4334-161X)
- Yudong Wang (ORCID: https://orcid.org/0000-0003-4251-4109)
- Shujun Gao
- QiaoWen Lu
Institutions
- Shanghai Medical College of Fudan University (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Biology of Reproduction
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1093/biolre/ioag054
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00