A Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension
Our data suggest that a change of cell identity (cFBs to cMFBs) in the RV is a driver of RV decompensation. TNF-α or rs659366 is a potential biomarker for early RV decompensation in PAH.
Authors
- Jiyuan Piao (ORCID: https://orcid.org/0000-0002-4435-7285)
- Evangelos D. Michelakis (ORCID: https://orcid.org/0000-0003-0787-7721)
- Yongneng Zhang (ORCID: https://orcid.org/0000-0002-0791-9381)
- Steeve Provencher (ORCID: https://orcid.org/0000-0001-7535-9972)
- Sébastien Bonnet (ORCID: https://orcid.org/0000-0001-5753-1900)
- Sarah‐Eve Lemay (ORCID: https://orcid.org/0000-0002-6625-9918)
- M. Mendiola
- Alois Haromy (ORCID: https://orcid.org/0000-0003-4744-9879)
- Yuan-Yuan Zhao
- Yongsheng Liu (ORCID: https://orcid.org/0000-0001-8551-8076)
- Sandra Breuils-Bonnet
- Gopinath Sutendra
- Dawn E. Bowles
Institutions
- University of Alberta (CA)
- Duke University (US)
- SNC-Lavalin (Canada) (CA)
- Duke Medical Center (US)
Publication Details
- Journal
- Circulation
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1161/circulationaha.125.078674
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00