Mathematical analysis of a tumor suppression model incorporating vitamin intake

Cancer is the second leading cause of death worldwide and occurs when cells uncontrollably divide, grow, and invade surrounding tissue. Several treatment strategies have been introduced to increase survival rates; however, each approach has potential side effects. Consequently, demand for alternative treatment approaches, such as immune system enhancement with vitamins, is growing. Here, we introduce a mathematical framework based on ordinary differential equations to examine the interactions among nutrients, immune cells, and cancer cells. Unlike many existing tumor–immune models, the proposed framework reveals that variations in nutrient levels can induce qualitative changes in system dynamics, including bistability and regime transitions between tumor-dominant and immune-controlled states. Long-term behavior, stability, and bifurcation techniques are employed. Numerical simulations are performed using the odeint solver in SciPy, which is based on the LSODA algorithm and is capable of handling both stiff and non-stiff systems. Our results suggest that optimizing nutrient levels can enhance the immune response, potentially leading to safer cancer treatment strategies.

Authors

Institutions

Publication Details

Journal
Discover Applied Sciences
Published
2026-03-09
DOI
https://doi.org/10.1007/s42452-026-08507-2
Primary Topic
Mathematical Biology Tumor Growth
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Mathematical analysis of a tumor suppression model incorporating vitamin intake

Kaushik Dehingia, Anusmita Das, Santosh Kumar Choudhary, Abdulwahed S. Alshaikhi et al.
Discover Applied Sciences
Mathematical Biology Tumor Growth
article

Mathematical analysis of a tumor suppression model incorporating vitamin intake

Kaushik Dehingia, Anusmita Das, Santosh Kumar Choudhary, Abdulwahed S. Alshaikhi, Yamen Alharbi, Suresh Babu Baluguri
article en

Abstract

Cancer is the second leading cause of death worldwide and occurs when cells uncontrollably divide, grow, and invade surrounding tissue. Several treatment strategies have been introduced to increase survival rates; however, each approach has potential side effects. Consequently, demand for alternative treatment approaches, such as immune system enhancement with vitamins, is growing. Here, we introduce a mathematical framework based on ordinary differential equations to examine the interactions among nutrients, immune cells, and cancer cells. Unlike many existing tumor–immune models, the proposed framework reveals that variations in nutrient levels can induce qualitative changes in system dynamics, including bistability and regime transitions between tumor-dominant and immune-controlled states. Long-term behavior, stability, and bifurcation techniques are employed. Numerical simulations are performed using the odeint solver in SciPy, which is based on the LSODA algorithm and is capable of handling both stiff and non-stiff systems. Our results suggest that optimizing nutrient levels can enhance the immune response, potentially leading to safer cancer treatment strategies.

Discover Applied Sciences
Khazar University (AZ), Manipal Academy of Higher Education (IN), King Abdulaziz University (SA), Adamas University (IN), Apeejay Stya University (IN), International Institute of Information Technology, Hyderabad (IN), Near East University (CY)
Good health and well-being
Openalex Percentile: Top 35%
Mathematical Biology Tumor Growth
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Mathematical analysis of a tumor suppression model incorporating vitamin intake — Kaushik Dehingia, Anusmita Das, et al. · Discover Applied Sciences (2026) | TGRS Research Map | TGRS