Impact of estradiol-to-progesterone ratio before progesterone initiation on pregnancy outcomes in frozen embryo transfer cycles with hormone replacement therapy: an analysis of over 25,000 cycles
In HRT-FET cycles, higher pre-progesterone E2/P ratios were associated with lower clinical pregnancy and live birth rates. The E2/P ratio may reflect the hormonal status of the endometrium, but its clinical utility requires confirmation through prospective studies.
Authors
- H. Ye
- Ping Huang (ORCID: https://orcid.org/0000-0001-7891-8848)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-5292-9087)
- Wei Liu (ORCID: https://orcid.org/0000-0001-8211-034X)
- Jun Shuai
- Xiu Luo
Institutions
- Chongqing Maternal and Child Health Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fendo.2026.1755013
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China