Metabolic profiling of the TME uncovers the contrasting impacts of CKMT2 and PDE2A in CRC progression and therapeutic response
PDE2A and CKMT2 were identified as critical metabolic biomarkers associated with distinct CRC subtypes and TME compositions. These findings highlight the intricate relationship between metabolic reprogramming, the tumor microenvironment, and tumor heterogeneity, providing insights into CRC molecular subtypes and their prognostic significance.
Authors
- Yuxiang Fu (ORCID: https://orcid.org/0009-0001-3109-7568)
- Liping Liu (ORCID: https://orcid.org/0000-0003-2943-055X)
- Kaiqi Huang
- Jianbo Lai
- Guixiang Liao
Institutions
- Southern University of Science and Technology (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fphar.2026.1732137
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00