HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription
Our findings define a novel HK2-H3K18la-CUX1-SASP signaling axis that drives URSA pathogenesis by linking metabolic reprogramming with epigenetic regulation. This work highlights CUX1 as a potential therapeutic target for correcting decidualization deficiency in URSA.
Authors
- Yuepeng Jiang (ORCID: https://orcid.org/0000-0002-1444-7183)
- Yiming Ma (ORCID: https://orcid.org/0000-0002-4654-5642)
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Hongli Zhao
- Yang Zhao
- Jing Ma
- Xiaoling Feng
Institutions
- Macau University of Science and Technology (MO)
- Zhejiang Chinese Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1186/s11658-026-00879-y
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00