α‐Linolenic acid suppresses Th17 cell differentiation to mitigate allergic rhinitis by binding to Lyn kinase in mast cells
Lyn kinase in mast cells plays a critical role in the pathogenesis of allergic rhinitis. ALA represents a novel Lyn-targeting agent, restoring immune balance by modulating mast cell-promoted Th17 differentiation, highlighting its potential for allergic rhinitis treatment.
Authors
- shiqiong luo
- Yujuan Yuan (ORCID: https://orcid.org/0000-0002-6763-4695)
- Yuejin Wang (ORCID: https://orcid.org/0000-0002-0833-211X)
- Chen Wang (ORCID: https://orcid.org/0000-0003-3995-4242)
- Hongfen Du
- Y. Zhang (ORCID: https://orcid.org/0000-0003-2029-0300)
- Yuanyuan Ding
- Ling Gong
- Xiaolan Ji
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1111/bph.70383
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00