CD19+Ki67+B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis

CD19<sup>+</sup>Ki67<sup>+</sup> B cells drive TNBC progression and brain metastasis by activating the NAMPT/ITGA5/ITGB1 pathway. These findings provide mechanistic insights into the immune regulation of TNBC BrM and identify potential therapeutic targets to improve clinical outcomes.

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Publication Details

Journal
Breast Cancer Research
Published
2026-03-09
DOI
https://doi.org/10.1186/s13058-026-02251-6
Primary Topic
Brain Metastases and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

CD19+Ki67+B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis

D. Jing, Qiyi Zhou, Yuxin Zhao, Liyuan Zhang et al.
Breast Cancer Research
Brain Metastases and Treatment
article

CD19+Ki67+B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis

D. Jing, Qiyi Zhou, Yuxin Zhao, Liyuan Zhang, Zhimin zhu
article en

Abstract

CD19<sup>+</sup>Ki67<sup>+</sup> B cells drive TNBC progression and brain metastasis by activating the NAMPT/ITGA5/ITGB1 pathway. These findings provide mechanistic insights into the immune regulation of TNBC BrM and identify potential therapeutic targets to improve clinical outcomes.

Breast Cancer Research
Central South University (CN), Soochow University (CN), Ministry of Agriculture (HU), Ministry of Agriculture (ID), Second Affiliated Hospital of Soochow University (CN), Xiangya Hospital Central South University (CN), Hunan Provincial Maternal and Child Health Hospital (CN)
No poverty
Openalex Percentile: Top 29%
Brain Metastases and Treatment
DOIOpen Access PDFOpenAlex
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CD19+Ki67+B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis — D. Jing, Qiyi Zhou, et al. · Breast Cancer Research (2026) | TGRS Research Map | TGRS