Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy
Results of this cohort study reveal that suicidality at the time of focal epilepsy diagnosis was associated with future drug resistance and may be a marker of more severe neuropathology. Psychiatric screening at time of diagnosis may facilitate early identification of patients at risk for treatment refractory epilepsy syndromes.
Authors
- Madeline Fields (ORCID: https://orcid.org/0000-0003-0661-4153)
- Rani K. Singh (ORCID: https://orcid.org/0000-0001-9343-6070)
- Tracy A. Glauser (ORCID: https://orcid.org/0000-0003-1520-2732)
- J. H. Pollard
- Sarah Barnard (ORCID: https://orcid.org/0000-0003-0517-2533)
- C. Ákos Szabó (ORCID: https://orcid.org/0000-0001-6731-3245)
- Edward Faught
- Alexis Boro (ORCID: https://orcid.org/0009-0004-6832-1107)
- Jerzy P. Szaflarski (ORCID: https://orcid.org/0000-0002-5936-6627)
- Jonathan J. Halford (ORCID: https://orcid.org/0000-0003-1681-6744)
- Caroline Neuray (ORCID: https://orcid.org/0000-0003-0716-7068)
- Judy Weisenberg
- Kimford J. Meador (ORCID: https://orcid.org/0000-0002-7471-882X)
- Kristen Park (ORCID: https://orcid.org/0000-0001-5527-3047)
- Brandy Fureman (ORCID: https://orcid.org/0000-0002-7862-4716)
- James C. Cloyd (ORCID: https://orcid.org/0000-0002-3607-6619)
- Margarita Kirschner
- Kamil Detyniecki (ORCID: https://orcid.org/0000-0002-8334-1403)
- Gary Cutter (ORCID: https://orcid.org/0000-0002-8455-980X)
- Scott Mintzer (ORCID: https://orcid.org/0000-0002-3285-5666)
- Brian K. Alldredge
- Dennis Dlugos (ORCID: https://orcid.org/0000-0003-3088-7645)
- Hamada Hamid Altalib (ORCID: https://orcid.org/0000-0001-7154-1400)
- Manisha Holmes (ORCID: https://orcid.org/0000-0002-4262-0764)
- David M. Ficker (ORCID: https://orcid.org/0000-0002-5991-0514)
- Dale C. Hesdorffer (ORCID: https://orcid.org/0000-0003-1783-5381)
- Simon Glynn
- John Hixson (ORCID: https://orcid.org/0000-0003-3053-6474)
- Patricia Penovich (ORCID: https://orcid.org/0000-0002-5831-8690)
- Eric B. Geller
- Jorge G. Burneo (ORCID: https://orcid.org/0000-0002-3644-2826)
- Barry E. Gidal (ORCID: https://orcid.org/0000-0001-6681-7134)
- Paul Atkinson (ORCID: https://orcid.org/0000-0001-9900-4594)
- Gregory L. Krauss (ORCID: https://orcid.org/0000-0002-0338-6039)
- Mary J. Brandon
- Siddhartha Nadkarni
- Lara Marcuse (ORCID: https://orcid.org/0000-0002-1494-7241)
- Patrick Kwan (ORCID: https://orcid.org/0000-0001-7310-276X)
- Nathalie Jetté (ORCID: https://orcid.org/0000-0003-1351-5866)
- Mangala A. Nadkarni
- Omotola Hope (ORCID: https://orcid.org/0000-0003-4600-1239)
- Graeme D. Jackson (ORCID: https://orcid.org/0000-0002-7917-5326)
- Heath Pardoe (ORCID: https://orcid.org/0000-0002-0123-2167)
- Zeli Chen (ORCID: https://orcid.org/0000-0002-1913-1364)
- Ernest Somerville (ORCID: https://orcid.org/0000-0001-8789-1122)
- Robert C. Knowlton (ORCID: https://orcid.org/0000-0002-5146-9664)
- Eugen Trinka (ORCID: https://orcid.org/0000-0002-5950-2692)
- Joon Won Kang (ORCID: https://orcid.org/0000-0001-5756-3814)
- Melodie R. Winawer
- Reeta Kälviäinen
- Ruben Kuzniecky (ORCID: https://orcid.org/0000-0002-3170-150X)
- David Gloss
- Sheryl R. Haut
- Pavel Klein
- Elisabeth Schmid
- Manu Hegde
- Bassel Abou-Khalil
- Martina Bebin
- DH Lowenstein
- Chris Morrison
- Andy Rodriguez
- Tricia Y. Ting
- A.M. Kanner
- Peter Widdess-Walsh
- Terence J. O’Brien
- Liu Lin
- Human Epilepsy Project Investigators
- Andrew Cole
- Jacqueline A. French
- Gregory Cascino
- Gregory Worrell
- Michael Sperling
- Susan Herman
- Orrin Devinsky
Institutions
- Houston Methodist (US)
- Northwell Health (US)
- Westchester Medical Center (US)
- University of Miami (US)
- Thomas Jefferson University (US)
- University of Calgary (CA)
- University of California, San Francisco (US)
- Yale University (US)
- Houston Methodist Sugar Land Hospital (US)
- Epilepsy Foundation (AU)
- Alfred Health (AU)
- Monash University (AU)
- New York University (US)
- Columbia University (US)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1001/jamaneurol.2026.0204
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00