Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy

Results of this cohort study reveal that suicidality at the time of focal epilepsy diagnosis was associated with future drug resistance and may be a marker of more severe neuropathology. Psychiatric screening at time of diagnosis may facilitate early identification of patients at risk for treatment refractory epilepsy syndromes.

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Publication Details

Journal
JAMA Neurology
Published
2026-03-09
DOI
https://doi.org/10.1001/jamaneurol.2026.0204
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy

Madeline Fields, Rani K. Singh, Tracy A. Glauser, J. H. Pollard et al.
JAMA Neurology
Epilepsy research and treatment
article

Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy

Madeline Fields, Rani K. Singh, Tracy A. Glauser, J. H. Pollard, Sarah Barnard, C. Ákos Szabó, Edward Faught, Alexis Boro, Jerzy P. Szaflarski, Jonathan J. Halford, Caroline Neuray, Judy Weisenberg, Kimford J. Meador, Kristen Park, Brandy Fureman, James C. Cloyd, Margarita Kirschner, Kamil Detyniecki, Gary Cutter, Scott Mintzer, Brian K. Alldredge, Dennis Dlugos, Hamada Hamid Altalib, Manisha Holmes, David M. Ficker, Dale C. Hesdorffer, Simon Glynn, John Hixson, Patricia Penovich, Eric B. Geller, Jorge G. Burneo, Barry E. Gidal, Paul Atkinson, Gregory L. Krauss, Mary J. Brandon, Siddhartha Nadkarni, Lara Marcuse, Patrick Kwan, Nathalie Jetté, Mangala A. Nadkarni, Omotola Hope, Graeme D. Jackson, Heath Pardoe, Zeli Chen, Ernest Somerville, Robert C. Knowlton, Eugen Trinka, Joon Won Kang, Melodie R. Winawer, Reeta Kälviäinen, Ruben Kuzniecky, David Gloss, Sheryl R. Haut, Pavel Klein, Elisabeth Schmid, Manu Hegde, Bassel Abou-Khalil, Martina Bebin, DH Lowenstein, Chris Morrison, Andy Rodriguez, Tricia Y. Ting, A.M. Kanner, Peter Widdess-Walsh, Terence J. O’Brien, Liu Lin, Human Epilepsy Project Investigators, Andrew Cole, Jacqueline A. French, Gregory Cascino, Gregory Worrell, Michael Sperling, Susan Herman, Orrin Devinsky
article en

Abstract

Results of this cohort study reveal that suicidality at the time of focal epilepsy diagnosis was associated with future drug resistance and may be a marker of more severe neuropathology. Psychiatric screening at time of diagnosis may facilitate early identification of patients at risk for treatment refractory epilepsy syndromes.

JAMA Neurology
Houston Methodist (US), Northwell Health (US), Westchester Medical Center (US), University of Miami (US), Thomas Jefferson University (US), University of Calgary (CA), University of California, San Francisco (US), Yale University (US), Houston Methodist Sugar Land Hospital (US), Epilepsy Foundation (AU), Alfred Health (AU), Monash University (AU), New York University (US), Columbia University (US)
Good health and well-being
Openalex Percentile: Top 37%
Epilepsy research and treatment
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