Targeting mitochondrial bioenergetics: the “Achilles’ heel” of Leishmania
Targeting the "mitochondrion" and metabolic reprogramming are effective leishmanicidal strategies adopted by HePC and Ampho B, with the degree of inhibition by HePC exceeding that of Ampho B. Accordingly, screening for compounds capable of mediating metabolic reprogramming could augment the limited armamentarium of antileishmanials.
Authors
- Sritama De Sarkar (ORCID: https://orcid.org/0000-0003-1203-1384)
- Deblina Sarkar (ORCID: https://orcid.org/0000-0003-2321-5728)
- M. Chatterjee
- Deep Goswami
Institutions
- Bose Institute (IN)
- Institute of Post Graduate Medical Education and Research (IN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1186/s13071-026-07247-x
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00