PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification
We identify a previously unrecognized posttranslational mechanism regulating PCSK9 stability in valve interstitial cells during calcific aortic valve disease and establish a link between PRMT3-mediated arginine methylation and valve-specific lipid-osteogenic coupling.
Authors
- Weicong Ye (ORCID: https://orcid.org/0000-0002-2044-6734)
- Xiaohan Li (ORCID: https://orcid.org/0009-0002-9947-2077)
- Yanglin Hao
- Yilong Li
- Kexiao Zheng
- Zifeng Zou
- Zetong Tao
- Li Zhang
- Xi Zhang
- Song Wang
- Dong Han
- Yinghuan Liu
- Xiaoke Shang
- Jiahong Xia
- Jie Wu
- Xin Jin
- Zheng Gan
- Yongjun Wang
- Ran Li
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Central South University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese PLA General Hospital (CN)
- World Wide Web Consortium (US)
- Second Xiangya Hospital of Central South University (CN)
- Huazhong University of Science and Technology Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Circulation
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1161/circulationaha.125.078830
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00