Integrative single-cell, spatial, and bulk transcriptomics reveal an FMR1–FTO axis linked to the immune-excluded phenotype in gastric cancer
Collectively, our data support an FMR1-FTO module associated with the immune-excluded phenotype and nominate this axis as a potential vulnerability for disrupting stromal immune barriers. The FMR1-FTO axis may represent a candidate target for strategies aimed at relieving immune exclusion and improving immunotherapy sensitivity.
Authors
- Li Zhao (ORCID: https://orcid.org/0000-0001-8015-3055)
- Meirong Liang (ORCID: https://orcid.org/0000-0002-4159-5026)
- Kangjie Zhou (ORCID: https://orcid.org/0000-0002-2090-2920)
- Fenglei Wu
- M Zhang
- Chenxi Mao
- Yiqian Han
- Yidong Hong
- Nan Hu
- Jingzhou Zhang
Institutions
- Xuzhou Medical College (CN)
- Lianyungang Oriental Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fimmu.2026.1713267
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lianyungang Science and Technology Bureau
- Xuzhou Medical University