Diagnostic challenges of histidine-rich protein 2-based rapid diagnostic tests due to pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria in Tanzania

The findings support the continued effectiveness of HRP2-based RDTs in detecting asymptomatic P. falciparum infections in Tanzania, despite the presence of some pfhrp2/3 gene deletions. However, the potential increase in deletion prevalence and the limitations of cross-sectional data highlight the need for ongoing molecular surveillance. Collectively, these findings provide a critical foundation for sustained surveillance and for clarifying the epidemiological significance of asymptomatic malaria in Tanzania.

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Publication Details

Journal
Infectious Diseases of Poverty
Published
2026-03-09
DOI
https://doi.org/10.1186/s40249-025-01397-3
Primary Topic
Malaria Research and Control
Type
article
Field-Weighted Citation Impact
0.00

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article

Diagnostic challenges of histidine-rich protein 2-based rapid diagnostic tests due to pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria in Tanzania

Sunghun Na, Wanjoo Chun, Winifrida Kidima, J. A. Han et al.
Infectious Diseases of Poverty
Malaria Research and Control
article

Diagnostic challenges of histidine-rich protein 2-based rapid diagnostic tests due to pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria in Tanzania

Sunghun Na, Wanjoo Chun, Winifrida Kidima, J. A. Han, Johnsy Mary Louis, WS Park, Won Suk Lee, Fadhila Fitriana, Hojong Jun, Jadidan Hada Syahada, Se Jin Lee, Feng Lu, Eun-Taek Han, Fauzi Muh, Ernest Mazigo
article en

Abstract

The findings support the continued effectiveness of HRP2-based RDTs in detecting asymptomatic P. falciparum infections in Tanzania, despite the presence of some pfhrp2/3 gene deletions. However, the potential increase in deletion prevalence and the limitations of cross-sectional data highlight the need for ongoing molecular surveillance. Collectively, these findings provide a critical foundation for sustained surveillance and for clarifying the epidemiological significance of asymptomatic malaria in Tanzania.

Infectious Diseases of PovertyVol. 15(1)
Diponegoro University (ID), Kangwon National University (KR), University of Dar es Salaam (TZ), Kangwon National University Hospital (KR), National Institute for Medical Research (TZ), Yangzhou University (CN)
National Research Foundation, Korea Health Industry Development Institute, National Research Foundation of Korea, Ministry of Science and ICT, South Korea
Openalex Percentile: Top 34%
Malaria Research and Control
DOIOpen Access PDFOpenAlex
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Diagnostic challenges of histidine-rich protein 2-based rapid diagnostic tests due to pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria in Tanzania — Sunghun Na, Wanjoo Chun, et al. · Infectious Diseases of Poverty (2026) | TGRS Research Map | TGRS