Sensory Nerves Regulate Odontoblast Differentiation via the SPP1/ITGA4 Axis During Tooth Root Development
Collectively, our findings elucidate a novel mechanism whereby sensory nerves orchestrate tooth root development by regulating progenitor cell fate through the SPP1/ITGA4 axis. This neuro-mesenchymal crosstalk provides insights for stem cell therapies and tooth root regeneration.
Authors
- Fei Pei (ORCID: https://orcid.org/0000-0002-0842-9245)
- Huanyan Zuo (ORCID: https://orcid.org/0009-0008-2616-5424)
- Jiahao Han (ORCID: https://orcid.org/0009-0008-0057-6452)
- Jiawei Wu (ORCID: https://orcid.org/0009-0002-1009-8294)
- Meng Liu (ORCID: https://orcid.org/0000-0002-7759-0681)
- Diduo Tian
- Yunjie Shuai
Institutions
- Wuhan University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1111/iej.70129
- Primary Topic
- dental development and anomalies
- Type
- article
- Field-Weighted Citation Impact
- 0.00