Efficacy of probiotic supplementation in preventing Clostridioides difficile infection: an umbrella review of systematic reviews and meta-analysis
Probiotic supplementation is associated with a reduced risk of CDI. However, given the variable methodological quality of the underlying evidence, these findings should be interpreted with caution. Population-specific and strain-specific effects require further investigation.
Authors
- Wenci Chen
- Xianjuan Pan
- Xinxin Lin (ORCID: https://orcid.org/0000-0003-4839-9041)
- Jing Ji (ORCID: https://orcid.org/0009-0000-6309-1593)
- Zhenhua Wu (ORCID: https://orcid.org/0000-0003-4552-883X)
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Medical University (CN)
- Wenzhou Hospital of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-03-09
- DOI
- https://doi.org/10.3389/fnut.2026.1699223
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Plan Project of Wenzhou, China
- Natural Science Foundation of Zhejiang Province