Central data monitoring of clinical trials: A survey of the UK clinical research collaboration (UKCRC) registered clinical trial units
Our survey shows the variety in the central data monitoring activities conducted by UKCRC CTUs and the variation as to who is conducting these activities. We recommend actions to improve the consistency and quality of monitoring in trials run by UKCRC-registered CTUs. When setting up new trials, CTUs should consider implementing the central data monitoring activities described, with particular emphasis on the eight activities undertaken by all units surveyed.
Authors
- Angela Casbard (ORCID: https://orcid.org/0000-0001-6241-3052)
- Sharon Love (ORCID: https://orcid.org/0000-0002-6695-5390)
- Lindsey Masters (ORCID: https://orcid.org/0000-0002-1587-8065)
- Chris Hurt
- Jo Haviland
- Michelle Jasmine Lazaroo
- Lucy Kilburn
Institutions
- Institute of Cancer Research (GB)
- Queen Mary University of London (GB)
- University of Bristol (GB)
- MRC Clinical Trials Unit at UCL (GB)
- University of Southampton (GB)
- University College London (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Contemporary Clinical Trials
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1016/j.cct.2026.108282
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00