Modulation of K <sub>ATP</sub> channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress
Diazoxide may be a potential therapeutic candidate for oxidative stress-driven barrier dysfunction in gastrointestinal diseases. Future studies incorporating physiologically relevant stressors, such as LPS or H₂S, will be important to validate these protective mechanisms in contexts more directly related to microbial dysbiosis.
Authors
- Annamaria Di Turi
- Fatima Maqoud (ORCID: https://orcid.org/0000-0002-4520-1370)
- Domenica Mallardi (ORCID: https://orcid.org/0000-0002-0629-0972)
- Domenico Tricarico (ORCID: https://orcid.org/0000-0003-2726-0462)
- Marina Antonacci
- Antonina Orlando
- Simona Drago (ORCID: https://orcid.org/0009-0007-7279-331X)
- Eleonora Malerba (ORCID: https://orcid.org/0009-0005-6669-9904)
- Nicoletta De Lucia
- Francesco Russo
Institutions
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-03-09
- DOI
- https://doi.org/10.1111/bph.70379
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00